Improvement of Mitochondrial Function of Pituitary Gland of Male Rats by Hydroxytyrosol nanoparticles

Abstract

Background :Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH:ubiquinone oxidoreductase, or complex I, is the largest and least understoodcomponent of the mitochondrial oxidative phosphorylation system.Hydroxytyrosol (HT) is a major polyphenolic compound found in olive oil with reported anti-cancer and anti-inflammatory activities. Objectives: identification of neuroprotective effect of HT as well as effect on histopathological study on pituitary gland in rat. Methodology:In the present study,After 8 weeks of HTextract and nanosespension administration at doses of 50 and 50 mg/kg, the histopathology of pituitary glandmicroscopy observations did not reveal any morphological alteration in the tissue examined. Results: There were no differences between controls and test item treated animals. Our observations suggest that HT improves mitochondrial function through activation of the AMPK pathway in the pituitary gland in rat. Conclusions: Hydroxytyrosol (HT) has neuroprotective effect study,hydroxytyrosol and their nanoparticles has not pathological changes on pituitary gland as well as that HT improves mitochondrial function through activation of the AMPK pathway in the pituitary gland in rat.