Phototherapy with Gold Nanoparticles and a Diode Laser for Oral Squamous Cell Carcinoma of the Tongue in Rats

Abstract

Photon energy is selectively delivered and transformed into heat sufficient to produce cellular hyperthermia in plasmonicphotothermal therapy (PPTT), a minimally invasive oncological therapeutic method. The current study shows that in vivo PPTT treatment of rats is possible.plasmonic gold nanorods and a compact, portable device to treat deep tissue cancers a low-cost near-infrared (NIR) laser.Squamous cell carcinomas shrink dramatically in size in Direct (P< 0.0001) and intravenous (P< 0.0008) delivery of rats tongue were detected.pegylated gold nanospheres For both administration and tumour growth inhibitionOver a 30day period, resorption of >57 percent of the directlyinjected techniques was seen, with resorption of >57 percent of the directlyinjected techniquesand a quarter of the intravenously treated tumours.