Freaquency of Fcγriiia-158v/F Polymorphism in Systemic Lupus Erythematosus Patients with Lupus Nephritis.

Abstract

Background: Receptors for the IgG plays critical role in linking humoral and cellular immune response. The various FcγR genes may contribute to differences in infectious and immune related diseases in various ethnic populations. Allelic variants of FcγR confers distinct phagocytic capacities providing a mechanism for heritable susceptibility to immune complex disease. Numerous functionally relevant SNP variants and copy number variants have been characterized in the FcγR genes. Many of these variants have also been shown to associate with the risk to development of SLE and some have been associated with disease progression.

Aim: In this study we aimed to investigate whether the distribution of the FcγRIIIA  polymorphism determines susceptibility to Systemic Lupus Erythematosus with lupus nephritis in Indian patients.

Methodology: A total of 32 patients that fulfilled American college of Rheumatology classification criteria for SLE were included in the study. FcγRIIIA genotypes were determined by polymerase chain reaction based allotyping method with allele specific primers.

Results: The results demonstrated that FcγRIIIA-158V/F  polymorphism in 91% and FcγRIIIA-158V/V in 9% of the cases. It shows that FcγRIIIA-158 has susceptibility to SLE and lupus nephritis in Indian patients. To our knowledge this is the first study considering the frequency of FcγRIIIA polymorphism in Indian SLE patients.

Conclusion: To enhance our understanding of the functional role of the receptors in SLE future research will need to integrate the knowledge of SNP and CNV and the functional diversity of the receptors.