Comparison of Erythrocyte Morphological Markers in Patients with the First Ischemic Cerebrovascular Attack

Abstract

Background & Objective: Stroke is the third leading cause of death in the world. Preventive and therapeutic approaches in this field are weak and further understanding of molecular mechanisms helps to diagnose and treat more effectively.

Methodology: This case-control study was conducted on 55 patients with ischemic stroke and 55 healthy individuals as a control group. The control group was collected from the staff and patients admitted to Valiasr Hospital in other wards. Demographic variables of the two groups were homogenized and then venous blood samples were taken to measure biochemical levels and complete blood counts.

Results: The mean age of patients was 69.98 years. The mean serum cholesterol level in patients was 157.1 mg/dL and it was 121.5 mg/dL in the control group and there was a statistically significant difference between the two groups (P <0.05). MCV was 88.5 in patients and 83.2 in the control group with a statistically significant difference. Systolic and diastolic blood pressure were also significantly higher in patients. In addition, serum ferritin and iron levels and hemoglobin were significantly associated with stroke severity (P <0.05).

Conclusion: The results of this study showed the relationship between erythrocyte morphology and stroke and based on this, more prospective studies can be recommended to evaluate the relationship between erythrocyte morphological markers and practical ways to prevent stroke.