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Plant extracts are complicated mixtures of phytochemicals. Plant derived products used in therapy continue to be a major source of beneficial drugs as most of the medicinal plants have pharmacological activity.This study aimed to assess the cytotoxic effect of Ocimum tenuiflorum on different cell lines (MCF-7, MDA-MB-468 and MDA-MB 231). For achieving this different doses of leaves extract were taken and introduced into cancer cells lines were recorded at 72 hrs respectively. The experiments are done in triplicates and values are expressed as mean ±SEM. The value of IC50 for different cell lines are as follows, be 1119 ± 102 nM, 1379 ± 167 nM, 1719 ± 120 nM and 3919 ± 602 nM respectively. O.tenuiflorum leaf extract alone is cytotoxic to MCF 7, MDA-MB-231 and MDA-MB-453 cancerous cell lines and reduces the CNVs, suggesting the very significant correlation with cell viability. Interestingly, we observed significant decrease in cell survival in these cancer cell lines when treated with the extracts of leaves.