Prevalence and Risk factors of Proteinuria associated with Hypomagnesaemia among Chronic Kidney Disease Patients

Abstract

Background: Magnesium is the second-most abundant intracellularcation after potassium and, which plays an important role in several biological processes Hypomagnesaemia is involved in the pathophysiology of hypertension, vascular calcification and metabolic derangements including diabetes mellitus and dyslipidemia, which are all risk factors for cardiovascular disease; the leading cause of mortality and morbidity in all stages of chronic kidney disease (CKD) Aim of the Study: Our study aimed at investigatingthe prevalence and risk factors of Hypomagnesaemia associated with proteinuria and its impact on CKD patients Patients and Methods: Our study was a cross-sectional study, included 132 subjects in 3 groups; Group I: comprised 50 proteinuricpatients with a mean age 50.64±13.48 years, Group II: comprised 50 non proteinuric with a mean age 50.16 ± 11.31years and Group III: comprised 32 end stage renal disease patients with a mean age 46.94±13.89 years.All subjects of this study underwent full medical history talking ,clinical examination and laboratory investigations.Results:There was statistically highly significant difference between the studied groups as regard Magnesium level; and the prevalence of hypomagnesaemia among proteinuric patients was 22%. Conclusion:Patients with CKD have a high prevalence of proteinuria associated Hypomagnesaemia which may be considered as a good predictor of mortality among CKD patients.