Main Article Content
Benzothiazole derivatives play vital role in some biological applications. The important coordinating sites of the Benzothiazole derivatives have participated in the preparation of many complexes. In this study, a number of Cu(II) and Hg(II) complexes of N-(benzothiazol-2-yl)benzamide(Btba) containing co-ligands such as Amines (2-aminopyridine, 3-aminopyridine, 4-aminopyridine, Bipy, Phen) or diphosphines (dppm, dppe) have been prepared. The prepared complexes have been characterized by Molar conductivity, magnetic susceptibility, UV-VISspectra, IR spectra, 31P-NMR, 1H-NMRand 13C-NMR spectra. The suggestion of geometric around the metal ions can be tetrahedral form. That the (Btba) ligand acted like a bidentate ligand through the N atom of five member ring in benzothiazole and O atom of carbonyl group, while the amines or diphosphines ligands coordinated through the N atoms or P atoms respectively, where the dppm ligand behaves in complex [Hg2(Btba)2(dppm)2]Cl4 (9) as a bridge ligand while the dppe behaves as a bidentate ligand in complex [Hg(Btba)(dppe)]Cl2 (10).
The biological activity of these prepared complexes against four bacterial species was investigated in this study: Staphylococcus Epidermidis and Staphylococcus aureus (gram positive) and E. Coli, CitrobacerFreundii (gram negative) (gram negative). As a reference, amikacin was used. The prepared complexes were more effective than amikacin against Staphylococcus epidermidis. The (9) complex, on the other hand, was more active against Staphylococcus aureus than amikacin until at minimum concentration. In the minimum concentration, the (3,5,6,8, and 10) complexes were more active against E. Coli,and the (1,3,4,5,7,8,9, and 10) complexes were more active against Citrobacterfreundii than amikacin.