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Therapeutic plants such as Solanumnigrum have been utilized as treatment of venomous bites. Combining these plants with antiserum is hypothesized to result in a better outcome more than utilizing of either treatment alone. Hence, this study points to validate the utilize of Solanumnigrum as an antivenom by extricating and recognizing the proteins of this plant.The sequences of 358 Solanumnigrum proteins were submitted to PSI-Blast to search for homologous snake proteins. The resulting 80scorpion proteins were subjected to multiple sequence alignments with the 358 Solanumnigrum proteins. A phylogenetic tree analysis resulted in 79 nodes in 26 clades, three of which contained scorpion proteins clustered with similar Solanumnigrum proteins. Homology modeling and structural comparison showed that three clustered scorpion proteins (2M01, 4AEI and 1J5J )were similar to proteins from Solanumnigrum. These scorpion proteins2M01, 1J5J and 4AEI shared at least 5% similarity to Solanumnigrum Q31952, P93847 and P27322 respectively.Themethod used in the current study validates the use of several Solanumnigrum proteins as agents to reduce the toxicity of scorpions’ bites.