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Abstract: The scientific significance of the results of the study is explained by the selection of early maturing, high-yielding varieties and specimens of bread wheat with high technological quality of grain and resistance to heat, drought and disease, based on the assessment of different eco-geographical groups. During the selection process, 24 specimens were selected for use in selection and crossbreeding, and in order to study 30 varieties and specimens in comparison with 6 regionized and promising varieties, agro-ecological varietal testing nurseries were established. Experiments were conducted in three sites: desert, middle and foothill areas of the region (Kasbi, Karshi and Shakhrisabz districts), for a comprehensive evaluation of varieties and specimens, their precocity and resistance to diseases, and testing them in different soil climatic conditions. The results obtained from the experimentation showed that the characteristics of the varieties and lines had varied in different soil and climatic conditions. Some bread wheat varieties and lines had stable, high and good quality yield in all three soil and climatic conditions. The practical significance of the results of the study is manifested in the form of high-quality grain yields achieved as a result of testing of varieties of bread wheat from the gene-pool of wheat with complex traits and characteristics in different agro-ecological regions, and these varieties have been included to the group of promising varieties and recommended for sowing in irrigated fields and farms of Samarkand, Surkhandarya, Tashkent, Andijan and Kashkadarya regions.