Cardiovascular Disease and its Correlation with Fibroblast Growth Factor-23: (Clinical Study for Babylon Patients Province)

Abstract

This paper is try to study the relation of fibroblast growth factor with developments of cardiovascular disease (VCD) under certain conditions. It’s well-known that CVD is a disease that affects the heart or blood vessels.
Cardiovascular diseases include atherosclerosis, coronary artery disease, heart valve disease, arrhythmia, heart failure, hypertension , orthostatic hypotension, shock, endocarditis, diseases of the aorta and its branches, disorders of the peripheral vascular system, and Congenital heart disease. Aims: To determine if Fgf 23 is a useful biomarker for detecting of cardio vascular disease for Babylon province patients. Method: The study included sample (blood) collection from g 88 patient ( 49male , 39 female) aged 40 to 60 years (mean age, 45.54 ±0.71665 divided into two groups (44)healthy and (44)patients. The experimental research work was conducted during the period (from 20th of Oct.2020 till 30th Jan.2021) in the labs of Biochemistry Department –Collage of Medicine –University of Babylon. The investigation of these parameters were measure by Enzyme Linked Immunosorbent Assay (ELISA) techniques. Result:For the experiment data analysis the g study shows a significant increase in the concentration of Fgf23,where(p˂0.05)was with the control group ,the elevated levels of FGF-23 in patients indicate a good sign for patients that needed cardiovascular therapy. On the other hand the levels of vit.D in controls was within normal value as compared with the patient reduce than normal. also result of FGF23g Roc the percent of area under the curve was 68% Conclusion:.the study shows Fgf 23 played a crucial role in cardiovascular disease development ,and further investigation must be added about particle materials (PM) intensity with it’s effects on CVD population