Evaluation of Different Steroid Nasal Spray in Chronic Rhinosinusitis: A Comparative Study

Abstract

Aim: In this study, we compared the efficacy of fluticasone propionate (FP) and mometasonefuroate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.

Methodology: For this study, 60 chronic rhinitis patients based on inclusion criteria were randomly assigned to two groups: FP and MF groups. FP group received 200 μg dose of FP nasal spray (2 sprays/nostril) daily and the MF group received 100 mg dose of MF nasal spray (2 sprays/nostril) daily for 8 weeks. The effects of the two agents were compared based on TNSS questionnaire in 0, 4 and 8 weeks after the beginning of the treatment.

Results: Patients in both groups exhibited significant improvement in their TNSS (P Value<0.001). A detailed TNSS analysis showed MF to be more effective for relieving all symptoms than FP. The most difference is in decreasing postnasal discharge (PND) symptom. However, the difference for relieving all symptoms is not significant (P value>0.05).

Conclusion: In conclusion, FP and MF are significantly effective in relieving of chronic rhinitis symptoms. Even though, the difference between the two is not significant for 8 weeks therapy.