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Pistaciaintegerrima is used as antihyperglycemic agent associated with diabetes. In present study the antihyperglycemic study of ethanolic extract from leaves of Pistaciaintegerrima (EEPI) was studied in wister ratof either sex by giving 200mg/kg to rats. Antihyperglycemic study was observed by using alloxan induced hyperglycaemia. Lipidemic activity in the same animal was studied. One-way ANOVA followed by Donnette multiple Comparisons test was used. EEPI significantly decreased (P<0.01 and P<0.001) alloxan induced hyperglycaemia and lipidemic effect of the extract. Effect of alcoholic extract of EEPI on body weight in the alloxan induced hyperglycaemic rates after 12 days of treatment were also observed. These results showed that EEPI exerted an inhibitory effect on alloxan induced hyperglycaemia which may justify its traditional use as an antihyperglycemic agent. Thus, from the study it is concluded that the leaves of P. integerrima afford antihyperglycemic activity by preventing hyperglycaemia in diabetic animal model.