GluN3A Receptor mRNA Expression in Adolescents Experiencing Nicotine Addiction Disorder and Internet Addiction

Abstract

The prevalence of people experiencing substance addiction and behavior addiction disorders is increasing every year. The criteria for addiction are characterized by tolerance (increased dose, withdrawal (withdrawal) and obsessive thoughts about the use of the substance. The most common addictions in adolescents are nicotine addiction and internet addiction, which have several adverse effects on the user. Nicotine as an ingredient.Contained in cigarettes, many cause high addiction rates in adolescents. Internet use is increasing in several levels of society, especially in adolescents. The incidence of internet use causes many problems, especially in cases of internet addiction. behavior has been studied a lot, including many biological factors play a role in the case of addiction. One of them is a disturbance in the neurotransmitter and its receptors. Some of the neurotransmitters that play a role are dopamine, GABA, Glutamate, Serotonin and Norepineprin. Glutamate in cases of addiction. In general, this study aims to determine the expression of Glutamate receptor mRNA in adolescents who experience nicotine addiction and internet addiction.

Method: Analytical research using a cross-sectional design by looking at the expression of mRNA Glutamate receptors in adolescents who experience nicotine addiction and internet addiction were analyzed by proportional difference test.

Discussion: The results found that the expression of GluN3A mRNA in the Nicotine group was lower than the Internet Addiction group with a significant p value of 0.000. The existence of a basic deficiency in the expression of the GluN3A subunit in people prone to addiction could form the basis of further studies with the control group and as a consideration in the choice of therapy.