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Recurrent miscarriage is the occurrence of two or more consecutive losses during the first or second trimester of pregnancy and affects 5% of couples and 1% have three or more consecutive miscarriages. This process is exhausting and both psychologically and physically disturbing for the couple, since 50% of recurrent miscarriages have unknown causes,But our research included increase homocysteine resulting from a deficiency of B vitamins (B12 and Folic acid) as hyperhomocysteinemia is associated with diseases that are mediated by the placenta, such as preeclampsia or placental abruption. Therefore, the aim of the study was to measure the levels of homocysteine in women who had two or more consecutive miscarriages and to evaluate the effect of vitamin B supplementation on homocysteine. To find out if lowering homocysteine can give good outcomes in women suffering from recurrent miscarriages of unknown causes.
The study included (135) women (45 control and 90 patients). The women suffering from two consecutive miscarriages or more, were divided into two groups, 45 pregnant women and 45 non-pregnant women, which were compared with 45 pregnant women (control group) who did not suffer from a previous miscarriage and had at least one previous birth. Miscarriages for known causes were excluded from our study
The results showed a significant increase in the level of homocysteine in the group RPL pregnant compared to the control group P≤0.05 and the level of vitamin B12 and folic acid significantly decreased compared to the control group. Also, there was a significant increase in homocysteine serum in the PRL non-pregnant group compared to the control group (P≤0.05) and a significant decrease in the level of vitamin B12 and Folic acid compared to the control group.
In addition, the results showed an inverse relationship between the level of homocysteine and B vitamins (B12 - Folic acid).
Hyperhomocysteinemia is a risk factor for recurrent miscarriage ( RM ) with low B vitamins(B12, folic acid ). Vitamin B supplements may be beneficial for women with a history of recurrent pregnancy loss.