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Aims: The study aims at determine the effectiveness of the educational program on nurses' knowledge about Pneumothorax attendant with mechanical ventilation. Methodology: A quasi-experimental research design was used with a pre- and post-test strategy for both the studied and control groups to achieve the study's goals. A total of (60) nurses who served in an intensive care unit during the research period, met the study requirements, and agreed to take part in the study. Data were analyzed with the aid of descriptive-inferential statistics. Results: There is a non-significant difference between the study and control groups at p-values greater than 0.05 in the pre-test, but a significant difference between the study and control groups at the post-test with p-values less than 0.01 in the post-test. In terms of the statistical mean, the research results show that after implementing the program, the study group responses increase as compared to the control group. Conclusion: After the post-test for the study group for the educational program concerning pneumothorax attendant with mechanical ventilation, nurses' knowledge improved. The control group, on the other hand, did not show any improvement in their awareness between the pre- and post-tests. Encourage nurses to attend training sessions to develop their skills and practice in order to stay current on pneumothorax prevention while using mechanical ventilation.