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Background: Antioxidants have a great influence on the control of oxidative stress and free radicals, and they cause the expression of apoptosis genes. Therefore, they have an important role in preventing cancer. The aim of this study was to Mechanism of ascorbic acid apoptosis on p53 and Bcl2 gene expression in AGS cell line. Method: To investigate the cytotoxicity influences of the treatments, the MTT test was applied to test the impact of various concentrations of ascorbic acid on the gene expression of p53 and Bcl2 using Real-time PCR. Results: The findings revealed that the mortality of the cancer cells enhanced significantly by treatment, compared with the untreated cells. The treatment, compared to untreated group, significantly affected the gene expression of p53 and BCL2. Conclusion: the results indicated that might be effective in inhibiting the growth of cancer cells.