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Aims: Our aim was to study the comparison of levobupivacaine with clonidine or dexmedetomidine in supraclavicular brachial plexus block for sensory, motorblock, analgesia sedation, hemodynamics and side effects. Methods and Material: 60 patients were subsequently randomized using „slip in a box‟ technique into two groups of 30 each as under.Patients were given 30 ml of 0.5% levobupivacaine with 150 mcg of clonidine (Group LC) or 100 mcg dexmedetomidine (Group LD) respectively. Time for onset of sensory and motor block, duration of motor block and analgesia, intra operative hemodynamics and sedation, side effects, complications were assessed. Statistical analysis used: For Statistical analysis chi-square test and independent student„t‟ test were applied by SPSS software (version 22) and p-value <0.05 was considered as statistically significant. Results:In Group LC and Group LD the mean onset time of sensory block was 8.87 (±1.78) min and 7.53 (±1.55) min respectively .Mean duration of motor block was 409.00 (±96.00) min while in group LD, it was 488.00 (±110.56) min. In group LC, the mean duration of analgesia was 805.00 (±114.11) min while in group LD, it was 1019.83 (±139.16) min. Conclusions: Dexmedetomidine when added to levobupivacaine as an adjuvant in supraclavicular brachial plexus block fastens the onset and have longer duration of motor and sensory blockade ,better sedation with no side effects as compared to clonidine .