Physiochemical Effect of Neonatal Jaundice on Some Liver Enzymes and Cholecystokin in Hormone

Abstract

This study was conducted with the aim of determining the relationship between some physiological and biochemical variables and the incidence of neonatal jaundice in newborns and comparing them with healthy group, the study include 120 blood samples were collected for children attending Fallujah Hospital for Women and Children for the period from October / 2020 to March / 2021, and it was divided into two groups of unequal number, namely the control group G1 and included 30 blood samples for healthy children and the second included (90) blood samples For children with congenital jaundice, the group of patients was divided into three groups according to the concentration of total bilirubin in the blood, each group included 30 samples, and they are the second group G2 with a concentration (10.6 - 13.9) mg / dl, and the third group G3 (14.0 – 17.6) mg / dl and the fourth group G4 (17,7-31,0) mg / dl, the result of this study recorded a significant decrease in the number of white blood cells in the three groups compared with the G1 control group. The results also showed that there was a significant increase in the activity of the ALT enzyme in groups of newborns patients with congenital jaundice compared to the control group. While there was a significant decrease in the activity of the AST enzyme with the same groups above. The results also showed that there was a significant increase in the activity of the ALP enzyme in the three groups compared to the control group. While the results showed that the G3 group with a concentration of (14-17.6) mg / dl showed a significant increase compared with the control group G1 and other affected groups. The results also showed that there was a significant increase in the effectiveness of CCK hormone in the three groups compared to the control group. We conclude from this study that there was a significant increase between ALT, ALP and CCK with jaundice, while there was a significant decrease between AST and WBC with jaundice.