Comparing Transversus Abdominis Plane Block and Wound Infiltration without Liposome Anesthetics in Adult Patients: Systematic Review and Meta-Analysis

Abstract

Backrub and aim: The aim of present systematic review and meta-analysis was comparing postoperative pain at rest within 24 h after surgery and postoperative pain during movement within 24 h after surgery of Transversus abdominis plane block and Wound infiltration without liposome anesthetics in adult patients. Method:From the electronic databases, PubMed, Cochrane Library, Embase have been used to perform a systematic literature between 2011 and May 2021. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included. Moreover mean difference with 95% confidence interval (CI), fixed effect model and Inverse-variance method were calculated. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata). Result:A total of 881 potentially relevant titles and abstracts were found during the electronic search. Finally, sixteen studies required for this systematic review. Meta-analysis showed lower postoperative pain scores at rest at 2,4,6,12 and 24 was h -0.66, -0.56 , -0.87 , -0.78 and -0.24, respectively (p<0.05) , except 1h was -0.30 (p>0.05). Also, postoperative pain scores during movement at 2, 4, 6 and 24 was -1.05, -0.65, -0.73 and -0.76, respectively (p<0.05), except 1h was -1.03 (p>0.05). Conclusion: Transversus abdominis plane block could lead to more effective analgesia than wound infiltration without liposome anesthetics in adult patients in 2 to 24 hours after surgery.