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Gestational diabetes is defined as a carbohydrate intolerance that is first diagnosed during pregnancy and affects the health of the mother and the fetus. Having a specific genetic polymorphism can be a predisposing factor to developing some diseases. This study aimed to investigate the linked between ADIPOQ gene SNP (rs 2241766) with the development of GDM. Genomic DNA from blood samples were extracted by using DNA extraction kit (Geneaid, Uk), then ADIPOQ gene was amplified through conventional PCR and SNP was discover using restriction enzyme SmaI. The results showed that there was a marked association between genotypes and alleles for SNP 45 T / G and GDM. GG genotype (O.R. = 1.94, C.I. 95% = 0.82-4.58), TG genotype (O.R. = 1.43 , C.I. 95% = 0.58-3.52) and G allele (O.R. = 2.27 , C.I. 95% = 1.24-4.13) it was more common in the GDM group compared to the control group. The results show genotypes GG, TG and allele G frequencies increased in GDM group (46.7%, 35.5% and 64.4%, respectively) than in control group (31.1%, 26.7% and 44.4%, respectively). In other hand, the genotype TT and allele T showed decreased frequencies in GDM group (17.8 and 35.6%, respectively) than in control group (42.2% and 55.6%, respectively).