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This study aimed to evaluate the effect of various doses of local apricot kernel on architecture of hepatic tissue and oxidant-antioxidant balance in serum and hepatic tissue. Twenty-four female albino rats were distributed into four groups randomly. First group administrated with distill water, second, third and fourth groups administrated with apricot kernel powder AKP 1.5g/kg, 3g/kg and 6g/kg respectively. Results revealed significant elevating in GSH and GPx in serum and GSH, SOD and CAT in hepatic tissue in groups administrated with 3 and 6 g/kg of APK. Moreover no alteration in MDA observed in all groups in compare to control. An elevation noticed in level of AST in administrated groups while no alteration in ALP. Histopathological study revealed a medium enlargement in hepatocyte with infiltration in a group treated with 3g/kg while there were a hypertrophy in hepatocyte, infiltration and congestion in a group administrated with 6 g/kg. We concluded that administration with 6g/kg APK may increase risk of liver cell injury, 3g/kg APK was less effect and 1.5 g/kg APK shows no alteration in compare to control.