The Association between Adipolin and Oxidative Stress for Diabetic Female Type II

Abstract

Obesity is a major public health issue closely linked to obesity-related disorders such as type 2 diabetes, atherosclerosis and hypertension. Adipose tissue secretes a variety of bioactive secretionary substances known as adipocytokines, the majority of which are pro-inflammatory and contribute to obesity-related disorders. Some adipocytokines, by contrast, have anti-inflammatory properties. Adipolin (CTRP12), which is an anti-inflammatory cytokine synthesized and secreted mainly in adipose tissue and reduces obesity and diabetes. Oxidative stress is another important factor in the pathogenesis of metabolism. It is a state of imbalance in cell and tissue systems, leading to the development of excessive free oxidative radicals and reactive oxygen species oxidative stress (ROS).
There were 54 patients with diabetes type 2 and 36 non-diabetic. Individuals of two groups of obese and non-obese compared with apparently healthy control. Before the body mass index (kg/m2) had been calculated, weight (kg) and height (m) were measured as a normal weight (18.49-24.99 kg/m2), or obese (> 30kg/m2) according to the WHO classification. Adipolin significantly decreased in obese diabetic patients compared with obese controls and it is low in the obese diabetic patients group compared to the nonobese patients group. TAC was significantly increased in the patients compared with controls (p < 0.05) and it was low level in obese diabetic patients compared with nonobese patients group, while MAD was high level in obese diabetic patients compared with nonobese patients group. The study also found weak negative correlated with MDA (r=-0.29, p= 0.13), TAC (r=-0.023, p=0.9), in obese diabetic patients while found weak positive correlated with MDA (r=0.037, p=0.85), TAC (r=0.35, p=0.69) in nonobese diabetic patients. Women patients with diabetes have low serum adipolin levels. MDA levels were high in obese patients compared with obese control while TAC levels were low in obese T2DM patients compared with obese control.