Cytokeratins in Glandular Odontogenic Cyst – An Immunohistochemical Study of 4 Cases

Abstract

Introduction: Glandular odontogenic cyst (GOC) is a relatively rare cystic lesion of the jaws, which poses a diagnostic challenge as well as a challenge in treatment. This study was conducted to evaluate the expression of cytokeratins in GOC and also to evaluate if cytokeratins be used as a diagnostic tool for GOC?
Materials and Methods: 4 cases were taken from archives of Department of Oral & Maxillofacial Pathology which were diagnosed as GOC histopathologically & Immunohistochemistry was done with 5 markers for each of 4 cases that are CK 7, CK 13, CK 14, CK 19 and CK8/18.
Results: The microscopic features which aid in its differentiation included presence of variable thickness of the lining epithelium, epithelial plaques and whorls, hobnail cells, ciliated cells, clear cells and goblet cells. Immunohistochemistry showed that epithelium of GOCs stained for CK 7, CK 13, CK 14, CK 19 with slight changes in their patterns, and no reaction to and CK8/18
Conclusion: Although GOC is relatively rare, correct diagnosis is of major clinical importance, since GOC has an aggressive potential, a high incidence of cortical perforation & a relatively high rate of recurrence, especially in cases treated with a conservative approach is observed.