Cerebrospinal Fluid Adenosine De Aminase and Lactate Levels as a Rapid Diagnostic Marker for Tuberculous Meningitis among Adults

Abstract

Tuberculous Meningitis (TBM) with a high mortality requires early diagnosis and prompt treatment. Current advances have brought out expensive investigations which help in early diagnosis of TBM. This study intends to bring out the diagnostic role of CerebroSpinal Fluid (CSF) Adenosine Deaminase (ADA) and lactate in differentiating TBM from non-TBM Objectives: To determine the role of CSF Adenosine Deaminase and lactate levels as a rapid diagnostic test for differentiating pyogenic and non-pyogenic meningitis in adults. Methodology: Cross sectional study involving 58 participants, with participants having presumptive Tb or TB by biochemical assays categorised as group A and the remaining participants as group B. Cut-off values for CSF ADA and Lactate were calculated using ROC, statistical analysis done and 95% confidence interval limits was calculated. Results: CSF ADA levels above 6.05IU/L had 9.24times chances of predicting TBM and those with CSF lactate levels above 47.0mg/dl had 18.0 times greater chance of being diagnosed with TBM. Conclusion: Widespread use of CSF ADA and Lactate, which are less expensive and undemanding especially in TBM helps in early diagnosis and prompt initiation of treatment.