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Morphine is known as a pain reliever which frequently prescribed globally. However, genuine result such as, dependence, pain relieving resilience, immunosuppression, gastrointestinal (GI) manifestations limit their utilization (12). The word Opium comes from the ancient Greek OPOS which means means vegetable juice. It is also refer to the Opium Poppy (Papver somniferum) (1). In order to overcome tolerance, a higher dosage of morphine is commonly used, although this technique leads patients to a greater risk of having serious side effects, such as morphine reward and withdrawal symptoms (4).