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The aim of study was to determine the relationship between Methylenetetrahydrofolate Reductase Polymorphisms in vitiligo with some clinical and blood parameters which include amount of hemoglobin in whole blood , RBCs and WBCs , the study included 60 patienthave been diagnosed with Vitiligo and 40 healthy people as a control group . The samples were collected from, Al-Kafeel Specialist Hospital, Imam Al-Hussein Teaching Hospital, blood were examined for all patients and control, and genetic polymorphism of gene rs1801133 C / T were studied using PCR-ARMS technology, the results were as follows: According to the of age of the subject were classified into five groups (5-15 years, 16-25 years, 26-35 years, 35-45 years, 46-55 years) the number and percentage of each category in vitiligo patients was 5 (8.33%), 6 (10%), 12 (20%), 17 (28.33%), 20 (33.34%) respectively, and while the healthgropuswere as follows: 4 (10%), 5 (21.5%), 8 (20%), 10 (25), 13 (32.5%), respectively. As the results showed by dividing the healthy and patient according to gender, the percentage of males was found in 34 (56.66%) and females 26 (43.34%), compared with the control group 50% for both sexes, allele frequency and genotype frequency. On the other hand the Methylenetetrahydrofolate reductase polymorphism was determined as the following : AA genotype, was recorded as 13 patients, AT genotype 27 and TT genotype was 20, while in healthy subjects 10, 11, 19 for each of the TT, AT and AA genotypes, respectively.