Antigens of the HLA System and Indicators of Immunogenetic Status - As a Means for Predicting the Adaptive Capabilities of the Body of Athletes to Increased Physical Activity

Abstract

The article studies the nature of the immune response in response to typhoid vaccination in athletes of the Uzbek population. The dependence of the immune response on the characteristics of the HLA-phenotype has been established: a high level of immunoreactivity and production of specific antibodies is characteristic of individuals - carriers of the HLA-B15 antigen in the phenotype; a low level of immune response and a titer of specific antibodies were detected in the presence of HLA-B5 and HLA-B35 antigens in the phenotype. The nature of the immune response, taking into account the HLA-phenotype, reflects the adaptive capabilities of athletes and can be successfully applied in sports selection. A sharp decrease in the frequency of occurrence of antigens HLA-A11, HLA-B35 in the group of highly qualified athletes was found in comparison with dischargers (P <0.05).