Ceruloplasmin Concentration in Patients with Chronic Liver Disease

Abstract

Ceruloplasmin (CP) is a glycoprotein containing copper located in the globulin part of human blood serum α2. More than 90 percent of the copper in the circulation of healthy human is carried by Ceruloplasmin secreted from hepatocytes that give powerful antioxidant and avoids lipid peroxidation through removing oxygen radicals. Metabolism of CP and function disorders occur in a number of liver diseases. This study was conducted in Hilla city, from October 2020- April 2021. The samples were collected from Babylon Center of Internal Medicine and Cardiology in Marjan Teaching Hospital in Hilla city Babylon Province.This study was included 86 (44 males, 42 females) subjects, which were divided into two groups 50 (26 males, 24 females) patients with chronic liver disease, and 36 (18 males, 18 females) apparently healthy persons as a control group. Ceruloplasmin concentration were determined by use enzyme-linked immunosorbent assay (ELISA) technique, The results of the present study were shown CP concentration not differ significantly between these groups .The present study advises to carry out genetic study for ceruloplasmin gene and CP concentration in patient with chronic liver disease as well as control.