Preparation, Characterization and Study Biological Activity of some New Metal Chelate Complexes Derived from Ligand Azo–Schiff for HetrocyclicThiazole

Abstract

This Work included the preparation of the ligand 4-[{(z)-4-florobenzylidene)amino}-2-(thiazol-2-yldiazenyl)phenol] from the preparation of the Schiff base by reacting para-aminophenol with 4-Flurobenzaldehyde to obtain schiff base as a first step. After that, the diazonium salt resulting from 2-amino thiazolewas coupling with Schiff base as a second step. Above is a component that pairs in an alcoholic base circumference to obtain the azo-Schiff derivative. Also, nine chelating complexes were prepared for the ions of each (Mn(II), Fe (II), Co (II), Ni (II), Cu (II), Zn (II), Pd (II), Cd (II), Hg (II). The results show that the mole ratio (metal - ligand) is (1: 2) and for all the complexes under study except for the palladium complex, whose molar ratio is (1:1). The ligand and its complexes were characterized by (C.H.N), molar conductance, magnetic susceptibility, FTIR, UV-Vis, HNMR, and mass spectroscopy. Based on the obtained results, an octahedral geometrywereproposed for all chelate complexes except for the palladium complex, which has square planar geometry around central metal ion. The research also included a study of the biological effect of this ligand and its metal complexes on the growth of two types of bacteria by using the solvent DMSO and the technique of spreading on the media of the blemishes as anti-bacterial Staphylococcus represented by bacteria positive for Gram stain (Gram positive bacteria) and bacteria Escherichia coli represented by bacteria negative for (Gram negative) Bacteria cause many common diseases.Where it was found that this ligand and its metal complexes have different biological efficacy as antagonists in inhibiting the growth of bacteria. The study has shown that the ligand and the prepared metal complexes have biological activities and when compared with the drugs Fluconazole and Cephalexin it is revealed that they can be used as medicines in the field of medicine.