Darier's Disease: A Comprehensive Review of Literature

Abstract

Darier-White disease is known as keratosis follicularis as well, is an autosomal dominant inherited keratinization disorder that affects the skin, nails, and mucosal membranes. This disease has a chronic and usually recalcitrant treatment challenging course also has a great impact on patients’ quality of life. In this comprehensive review article, we searched the most recent and related articles related to our topics and subtopics with emphasis on epidemiology and etiology, clinical symptoms, genetic changes and molecular pathogenesis, diagnosis and differential diagnosis, treatments and management also possible associations.