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Corona virus is one of the serious dangerous viruses that infect the respiratory system, which pose a great threat in the Middle East, including Iraq, which lacks a significant decrease in health services as a result of the military operations and wars that have passed on this country. In view of the large increase in the rate of infections in Iraq, this study suggested an estimate C-reactive protien and LDH levels as primary parameters for early detection of Coronavirus. In this work , rate of infected males with COVID-19 is higher than females .All samples were identified by routine diagnosis method and molecular diagnosis using qPCR. All study population (patients and control) were subjected to the evaluation of serum levels of CRP, and LDH. COVID‑19 patients showed a significant elevation in the levels of all parameters included in this study when compared with healthy controls. We also found that all of CRP, LDH are significantly associated with the severity of the COVID‑19 symptoms.