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Ganodermalucidumand Pleurotussajor-cajuare important mushrooms, which is used widely as food and medicine. One of the major concepts of siddha is food is medicine and medicine as food. To consider this the present study was conducted to assess anticancer potentials of extracts of Ganodermalucidum and Pleurotussajor-cajumixture with reference to cancer cell line cytotoxicity by MTT assay.Intracellular reactive oxygen species assay and mitochondrial membrane potential of extract and control treated cell lines were assessed by making use of standard textual procedures. Results revealed that aqueous and ethanol extracts of mushroom mixture control the growth of MCF-7 cell lines growth upto 71%, which was also evident in ROS generation and mitochondrial membrane potential assay.