A Review of Antifungal Activities of Various Flouroquinolone and Its Metal Complexes

Abstract

Superficial fungal infections are common worldwide.Fungal infections are a growing challenge in immunocompromised patients. The prolonged use of traditional antifungals to treat fungal infection has caused the emergence of drug resistance, Therefore, demand of new therapeutic strategies for fungal infections are warranted. Quinolones and Flouroquinolones displayed potential anti-fungal activity and some of them could significantly increase the susceptibility of antifungals.Metal complexes of Flouroquinolones with specified antimicrobial activities, are a new entry in the field of bioinorganic. Antifungal activities of few metal complexes of Flouroquinolones arereviewed in this paper by comparing the zone of inhibition values.Some of them found to exhibit excellent potency against both drug‐susceptible and drug‐resistant fungi where as some found to show lesser or no antifungal behaviour as compared to the parent drug.The objective of this review is to contour the recent advances in flouroquinolone derivatives as promising antifungal agents and summarize the coordination behaviour of the drug with metal ions to provide cognizance for the design of more active candidates.