Synthesis, Characterization and Biological Activity and Anti-Oxidant Study of Some New Thiazolidine Derivatives Containing Oxadiazole

Abstract

 The study included the preparation of compound 2-phenyl thiazolidine-4-carboxylic acid (T) which were synthesized from the reaction of Benzaldehyde with cysteine. This condensation afforded product as a mixture of diastereomers, Cis-(2R,4R) and Trans-(2S,2R), which could not be separated, The Cis/Trans ratios were  strongly dependent  on the nature of the solvent, which reacts with acetic anhydride for the preparation of compound 2-phenyl N-acetyl thiazolidine-4-carboxylic acid  (TA) . The two compounds (T),(TA)interact with isoniazid or benzohydrazide in the presence of POCl₃ to prepare 1,3,4-Oxadiazole derivatives(TAO_1,2 ,TO_1,2).  The compound(TA) was reacted with ethanol and then with aqueous hydrazine to prepare compound (TAH), which reacts with CS₂ and KOH to prepare the compound 1,3,4-oxadiazole-5-mercapto(TASO).  new synthesis compounds were identified by FT-IR,¹HNMR, ¹³CNMR and Mass Spectrum. The biological activity of some preparation compound were studied against two types of bacteria one of them were gram negative (s.paucimobilis) and other were gram positive (S.lentus ) and anti-oxidant and determine the IC₅₀.