Serum Lactate Dehydrogenase (LDH) Level as a Predictor of Severity of Preeclampsia

Abstract

Background: Preeclampsia is a disorder of the human pregnancy and is the leading cause of maternal death and morbidity of growing fetus. Is characterized by extensive endothelial dysfunction that produces hypertension, proteinuria and edema. Objective of the study: to compare the level of lactate dehydrogenase between normal and preeclamptic pregnant women and to assess the role of LDH as a predictor of severity of preeclampsia. Patients and method: Prospective study was carried in Gynecology and Obstetrical Department at Al-Zahra' a Teaching Hospital for Maternity and Pediatrics/ Najaf governorate/Iraq from the beginning of March 2019 to the end of August of the same year. The study population consists of 50 normotensive pregnant women and 50 preeclamptic pregnant women seen for their perinatal care in the third trimester of pregnancy. Results: the mean proteinuria in control and preeclamptic group are 0.04±0.1 and 2.3±0.6 respectively, and highly significant increase in preeclampsia than that in healthy women (P<0.001). The mean of plasma LDH activity for control and preeclamptic groups are 3.14±0.46 U/L and 6.5±2 U/L respectively with highly significant increase in plasma LDH among case groups than that for control (P value <0.001). Conclusion: Significant increase in plasma LDH in patients with preeclampsia than normal pregnant women