Association of IL-17 and IFN-g in Patients of Breast Cancer Infected and non-Infected with Toxoplasmosis

Abstract

Background:Breast cancer is the most-frequent malignant disease and the leading cause of death from cancer among women worldwide, both economically developed and developing countries.T.gondii is the more common protozoan parasites that cause opportunistic infections in individuals of immunocompromising.

Aims of the Study:Association the cytokines IL-17 and IFN-g in breast cancer patients Infected and non-Infected with toxoplasmosis andtoxoplasmosis only group.

Materialsand Methods: The case control study was conducted on 240 (60) patients with CA. Breast infected toxoplasmosis group, 60 patients with CA. Breast non-infected toxoplasmosis group, 60 patients infected toxoplasmosis without cancer group and 60 healthy controls group) . Both groups patients with CA. Breast were referred to Middle Euphrates cancer center in Najaf and private the clinics for Physicians Oncology , patients infected toxoplasmosis without cancer group were referred to Hospitals in Najaf  during the period  November2019 to October 2020. Measurement of IgG Toxoplasma and cytokines (IL-17 and IFN-g )  by using Enzyme Linked Immunosorbant Assay.

Results: The showed a levels of IgG Toxoplasma(144 ± 83.4 IU/ml), IL-17 (154.1 ± 55.9 ng/L) and IFN-g(46.6 ± 17.5 ng/ml) in patients of breast cancer infected toxoplasmosis higher  than in other studying groups.

Conclusions:A significant elevation  levelsIL-17 and IFN-g in breast cancer groups and toxoplasmosis only group in comparison with control and higher a significant elevation  levels of IgG, IL-17 and IFN-g in breast cancer infected toxoplasmosis in comparison with breast cancer non-infected toxoplasmosis.