Effect of BOTOX on Sex Hormones and Lipid Profile of Females Rats

Abstract

The present study aimed to investigate the effect of Botox on sex hormones level which including follicle-stimulating hormone (FSH), luteinizing hormone (LH) and progesterone in female rats and measurement of serum lipid profile. Two doses 0.1/ animal and 0.2 ml/ animal from Botox were used and the animals were injected intramuscular of botulinum toxin for 1 day as two dose only. The results showed a significant decrease (P<0.05) in the level of FSH and LH, with a significant increase the level of progesterone of the female treated with 0.1 ml and 0.2 ml of Botox compared with the control group. The results showed a significant increase in the level of cholesterol, TG, HDL, LDL and VLDL of the female treated with Botox at dose 0.2 ml when compared with the control group. While, the female treated with Botox at dose 0.1 ml there was no a significant in level of cholesterol compared with control group. Also, there was a significant decrease of HDL of female rats treated with Botox compared with control group. Injections of female rats with botulinum toxin are generally well tolerated and side effects are few. A precise knowledge and understanding of the functional anatomy of the mimetic muscles is absolutely necessary to correctly use botulinum toxins in clinical practice.