Lipid Profile, Serum Ferritin and Dyslipidemia in Survivors of Acute Lymphoblastic Leukemia

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Nesma Magdi Altantawy, Ahmed Gamal Alakhras, Laila Metwally Sherief, Osama Abdalaziz Gaber

Abstract

Background:The most common type of cancer in children is acute lymphoblastic leukemia ALL.Hereditary hemochromatosis (HH), a hereditary iron metabolic condition associated with tissue damage, is the major cause of elevating iron tissue concentration. The study aimed to Lipid profile, serum ferritin and dyslipidemia in Survivors of Acute Lymphoblastic Leukemia. Methods:This study was conducted at pediatric oncology out patient clinic at Children HospitalZagazig university&The Scientific Research Centre of Faculty of Medicine Zagazig university during the period from the 1st of July 2017 to the 15th of April 2018 on 50 of ALL surviors including 26 male &24 female and in addition 50 age and sex matched children were included as control group.The following investigations were done: CBC, Serum  ferritin and Fasting lipid profile. Results:Serum ferritin was significantly  higher in ALL survivors than the control. In the current study, lipid profile including serum cholesterol, serum triglycerides, serum LDL showing higher significance difference in ALL survivors than control group, while serum HDL is significantly lower in ALL survivors than control group.Conserning dyslipidemia among ALL survivors group, HDL was < 40 mg/dl among 10% and TG was above 150 mg/dl in 18% of the studied patients, all of them their cholesterol level is less than 200 mg/dl, and LDL was less than 130 mg/dl. Conclusion: Serum ferritin was significantly  higher in ALL survivors than the control. lipid profile including serum cholesterol, serum triglycerides, serum LDL showing higher significance difference in ALL survivors than control group, while serum HDL is significantly lower in ALL survivors than control group. Higher dyslipidemia among ALL survivors group.

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Nesma Magdi Altantawy, Ahmed Gamal Alakhras, Laila Metwally Sherief, Osama Abdalaziz Gaber. (2021). Lipid Profile, Serum Ferritin and Dyslipidemia in Survivors of Acute Lymphoblastic Leukemia . Annals of the Romanian Society for Cell Biology, 9281–9287. Retrieved from https://annalsofrscb.ro/index.php/journal/article/view/3667
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