The Role of the Hormone Hepcidinand Some Biochemical Variables in Patients with Kidney Stones

Abstract

   There is a significant correlation between kidney stones, type of food, environment, and the variety of medication taken, as well as genetic conditions, as well as the effect of the level of electrolytes on the formation of stones. This study was conducted in the laboratories of Kirkuk General Hospital and the Public Health Laboratory in Kirkuk Governorate from 1/12/2019 to 1/1/2021, Where the study included (60) samples of people with kidney stones ranging in age from (30-72) years, the number of men (32) men and the number of women (28) women, as well as (30) blood samples were collected from healthy people, where the number of men was (15) men and the number of women was (15) women, and they were chosen randomly from the residents of Kirkuk governorate.

This study also includes some biochemical variables: Levels of the hormone hepsidine and cortisol, And measuring the concentration of electrolyteschloride (Cl^-) and magnesium (Mg ⁺⁺), [and body mass index). In addition, the age relationship was studied and the number of times stones formed as well as gender were studied and compared with the control group. Where the current study showed:

The results showed that there was no significant difference in the levels of the hormone abelin in all the variables studied, as for the hepcidinhormone, the results showed a high significant decrease (p <0.0001) in the levels of the hepcidinhormone in the group of patients with kidney stones compared to the control group, as well as the results showed a significant difference. (p <0.0001) in the two groups of patients compared with the control group at body mass, and the results showed that there was no significant difference in the levels of the Hepatidine hormone when the rest of the variables studied,Also, a significant increase (p <0.0001) was found in their effect on the level of the hormone cortisol in the group of patients with kidney stones compared to the control group, and also a significant decrease (p <0.0001) was found in the levels of the hormone cortisol among the group of patients with kidney stones for female patients compared with males Patients, while there is no significant increase in patients for the rest of the variables studied in this study.