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Prolactin is a protein known as luteotropin, which enables mammals(females) to produce milk.This study evaluated the relationship between increasing prolactin levels and Chronic Kidney Disease (CKD). Blood sampleswere collected from 36patients with CKD and 35healthy people as a control group.Kidney function test was conducted, as the following parameters were calculated for both CKD patients and the control group: serum prolactin, insulin, insulin resistance, creatinine,glucose, uric acid,urea, albumin and total protein. Results showed that high levels of serum prolactin (57±3.21ng/dl) were observed in CKD patients in comparison to the control group (21±2.2 ng/dl). A significant difference (P˂0.05) was recorded in serum prolactin, insulin, insulin resistance, urea, creatinine and uric acid levelsbetweenCKD patients and the control group. Results also revealed that serum prolactin in CKD patients was higher in females (68±1.21ng/dl) than that recorded in males (47±3.22 ng/dl) in comparison to the control group for both males and females (19±1.2 and 23±2.4 ng/dl) respectively. Insulin resistance recorded nearly the same values in CKD patients for both males and females (5.99±1.12 and 6.39±0.51) respectively but higher than those recorded in the control group (2.79±0.31and3.07±0.31) respectively. Blood urea levels were considerably higher in males (81±3.11 mg/dl) than that recorded in females (72±3.11 mg/dl) for CKD patients in comparison to the control group for both males and females (15.8±2.1 and 14.3±3.1 mg/dl) respectively.