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The study aims to identify the influences of folic acid and propolis administration on rabbits treated with H2O2 and its effect on the adrenal gland. The adrenal gland has a component structure. It plays a role in a defensive role during stressful situations and facilitates reactions concerning fight or flight decisions. The adrenal cortex cells synthesize glucocorticoids (corticoids) and hormones that help to cope with stressful situations. The adrenal medulla cells secrete catecholamine class hormones, such as epinephrine and norepinephrine, that assist instantaneous responses. An experimental study design was done to determine the effect of propolis and folic on rabbits' protective effect and physiological from January 2019 to January 2020. Twenty New Zealand rabbits were ten male rabbits, and ten female rabbits were used in this experiment placed in metal cages under controlled conditions and environment. Twenty mature, healthy rabbits were split into two groups. Group 1 worked as control, while group 2, adminstration folic acid (8.3 µg/kg B.W.) and Propolis-water-extract (K2Cr2O7) orally for the twelve weeks. The mean age of rabbits is (7 M± 2 M) and an original weight before the study of (2.9 Kg ± 0.05 Kg). The current study shows that supplement of rabbit propolis and folic acid has a useful impact on reproductive functions, hormonal parameters. The effect of the folic acid and propolis content of significant amounts of antioxidant such as including minerals, vitamins, enzymes and phenolic ingredients. Therefore the recommended of that folic acid and bee propolis doses orally every day to the rabbits to enhance productive and reproductive function traits. But, additional experiments studies are necessary with large sample with multiple various dosages.