Protective role of Pomegranate juice Against Hepatotoxicity and Nephrotoxicity Induced by Haloperidol Drug in Male White Rats.

Abstract

The aim of this study is to investigate the protective effect of Pomegranate juice against haloperidol –induced hepatotoxicity and nephrotoxicity in male albino rats. In this study we used 30 male white rats and divided them into 3 equal groups. Each experimental group consisted of 10 animals as fallows: Group1: Control group: They were given only normal saline for 30 days. Group2: haloperidol: animals of this group were given haloperidol orally by gavage at a dose level of 1 mg / kg body weight, every day for 30 days. Group3: haloperidol + pomegranate juice (n=10): animals of this group were given haloperidol (1 mg / kg body weight) plus pomegranate juice (2 ml/kg body weight) by gavage, every day for 30 days.

  After 30 days, biochemical analysis were conducted to evaluate hepatotoxicity and nephrotoxicity. Serum levels of ALT, AST, ALP, total bilirubin, albumin, total protein, urea, and creatinine were measured. Animals treated with haloperidol alone showed a significant increase in serum levels of of ALT, AST, ALP, total bilirubin, creatinine and urea and significant decrease in serum levels of albumin and total protein compared with control group.

  Results of this study showed an improvement in the biochemical parameters of rats treated with combination of pomegranate juice with haloperidol (group3) compared with group2, and these parameters are near the in group1. Therefore pomegranate juice may protect against haloperidol induced hepatotoxicity and nephrotoxicity.