Role of Apelin in Egyptian Children with Type 1 Diabetes Mellitus

Abstract

Background: Adipose tissue yields many adipocytokines that modulate insulin sensitivity and play an essential role in the pathogenesis of diabetes. Apelin is a multifunction neuropeptide, involved in the regulation of food intake, cell proliferation and angiogenesis. This study aimed to investigate the role of apelin serum levels in children with type 1 diabetes mellitus (T1DM) and its relations with obesity and with some biochemical parameter serum levels. Methods: One hundred Egyptian children with T1DM and 50 healthy controls were involved in this study. Blood samples were withdrawn after 10 hours fasting for biochemical investigations of serum glucose, glycosylated hemoglobin (HbA1c), and apelin. Results: This study revealed that apelin concentration were higher in patients group comparing with control group, there is a significant increase in apeline by increasing weight. Conclusion: The increase of serum apelin in children may contribute to development of diabetes. These variations can be used as a specific marker in prediction of TIDM.