Evaluation of the Toxicological Effect of Silver Nanoparticles in Male Albino Rats Kidney: Histopathological Study

Abstract

 Recently, silver nanoparticles (AgNPs) have been widely applied in different fields such as cosmetics, pharmaceutical and medicinal industries due to its easiness in absorption the gastro tract there for This study was designed and carried out to find the AgNPs effect on the structure and the performance of the kidney tissues on the male albino rats. To carry out the experiment, and achieve this study, twenty-four male albino rates were selected, and weight, and they were divided into 3 groups, the first onewas considered as a control group and injected with normal saline solution, while the second group(treatment) was injected withAgNPs 0.75 mg/kg of body weight, and the third group (treatment)was conjected with AgNPs 1.5mg/kg of body weight. Each concentration of AgNPs was dissolved in one ml of normal saline. All the injections were achieved as intraperitoneal injection for 30 days every day with 1 mL injection. The damage in the tissues of the kidney was appeared histologically in renal tubules as fatty degeneration, and vacuolation, in glomerulus appear pyknic nucleus, and also as massive aggregation around the blood vessels precisely in mononuclear cells with hemosiderin, and hemorrhage in renal tubules. Also appeared the amyloid in the blood vessels These symptoms can be recognized when a certain factorwas compared between the control group with infected with AgNPs, particularly at the level of the kidney function such as creatinine, uric acid and in the urea. The dysfunction and the changes in histopathology of the kidney is related to the toxic effect of the silver nanoparticles which cause the occurrence in ROS (Reactive Oxygen Species) which play an important role and cause disorder in kidney.