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The thyroid gland is a highly vascular endocrine gland located anteriorly in the throat, stretching from the fifth cervical to the first thoracic vertebrae. Researchers discovered that in cases of moderate hypothyroidism, serum TSH levels were also elevated, while T3 and T4 levels remained within normal limits. Diffuse goiter is characterized by the enlargement of the entire thyroid gland and is seen in patients who have hypothyroidism or hyperthyroidism at puberty, while poisonous diffuse goiter, also known as grave's disease, is seen in hyperthyroid patients. It has been claimed that Diffuse Goiter (Simple) or physiological goiter is the most common thyroid disorder in various groups of peopleThyroid ailments. They also discovered that while diffuse goiter has equivalence with diffuse radioactive iodine uptake, multinodular goiter does not have equivalence with irregularity in uptake and activity in the thyroid gland.
Aim:Comparative study of thyroid profile in patients having diffuse goiter from RHTC and UHTC, SMHRC
Material and Methods:The study was conducted inDept. of Biochemistry, Datta MegheMedical College and Shalinitai Meghe Hospital and Research Center, Nagpur. This study included 150 subjects and was distributed in two groups. Group I included 75 diffuse goiter patients as study group and group II included 75 normal healthy individual as control group.
Result:In both the research and control groups, the mean level of T3 and T4 was (0.950.20, 0.800.17); it was markedly higher in the study group than in the control group (p 0 0001 and 0.0015, respectively). Goiter was more common in normal patients than in the research group (p 0.0001). TSH concentrations in the blood were higher in the research group than in the control group, and mean FT4 levels were higher in affected people than in healthy people.
Conclusion:According to the findings, goiter prevalence may be influenced by the degree of hormonal dysfunction, notably normal and abnormal TSH levels. In addition, the increased risk of goiter is linked to female gender and lower TSH levels, according to this study. 'The' For possible systematic review, an epidemiological profile of patients with diffuse goiter is required.look into it