Relation between Homocystine, Creatinine and Cholesterol in Overt Hypothyroidism

Abstract

INTRODUCTION

Hypothyroidism is a condition which is In serious cases, it is quickly detected and managed, but it can be fatal if left untreated. The description of hypothyroidism is based on statistical reference ranges for the respective biochemical parameters, and it is a hotly debated subject. Medical hypothyroidism can manifest itself in a number of ways, ranging from no symptoms to a life-threatening disease. Overt hypothyroidism is characterised as hypothyroidism with elevated TSH and low T4. The most common symptoms of hypothyroidism in adults are exhaustion, lethargy, cold aversion, weight gain, constipation, voice change, and dry skin, although clinical appearance differs based on age and sex, among other variables.Thyroid hormones can influence cholesterol metabolism, resulting in elevated serum cholesterol. Thyroid hormones may have a direct effect on renal function, tHcy metabolism, and kidney clearance, resulting in an increase in serum creatinine.

AIM: Relation between Homocystine, Creatinine and Cholesterol in Overt Hypothyroidism

MATERIAL AND METHOD: The present study included total 200 subjects that were divided in two groups. Group I contained 100 patients with overt hypothyroidism and Group II containd100 healthy individuals as control group. Blood samples from the subjects were collected and analysed for Serum Homocysteine, Serum Creatinine, Cholesterol and thyroid hormones FT3, FT4 and TSH.

RESULT:Total Homocysteine, Total Cholesterol, Serum Creatinine and TSH is significantly increased (P<0.0001) in overt hypothyroidism patients when compared them with the healthy individuals, while the patients with overt hypothyroidism had reduced FT3 and FT4 which was statistically significant as compared to control group.

CONCLUSION:Our analysis indicated that increased plasma tHcy, In overt hypothyroidism, total cholesterol and creatinine were found, as well as an inverse relationship between tHcy and FT4 and FT3, as well as a positive relationship with TSH.