To Assess Urinary Glutathione- S- Transferase Isoenzymes in Identifying of Acute Kidney Injury Following Heart Surgery

Abstract

BACKGROUND:Biological markers for acute kidney injury (AKI) have yet to be widely used in clinical practise, despite their promise of earlier detection and risk stratification. We measured urinary α and π glutathione S-transferases (α-GST and π-GST), glutathione S-transferase (GST) subtypes π and α as biomarkers of acute kidney injury (AKI) during heart surgery patients.GSTs' role in oxygen radical disposal and the pathogenesis of cardiac surgery and cardiopulmonary bypass (CPB)-associated AKI, as well as new insights into GSTs' site-specific expression in identified parts of the nephron during renal damage, are highlighted.

METHODS:This study at DMMC and SMHRCwanadongri Nagpur in collaboration with AVBRH sawangimeghewardha.80 subjects included in this research and divided in two groupsStudy group:40 subject AKI in after heart surgery and Control group: 40 subject healthy subjects.

RESULTS:α-GST increased in study group (20±2.03) as compared to control group (6.5±0.02) and urinary π-GST and serum creatinine level also increased in study group (16±0.09, 2.30±0.6) as compared to control group (13±0.06, 1.2±0.02).

In present study statistically both increase in urinary α-GST and urinary π-GST following adult heart surgery, but both α-GST and π-GST return to lower levels in 24 hrs.

CONCLUSIONS:  in the present research concluded patients data suggest a relation of urinary α-GST and π-GST in the early diagnostic evaluation of acute kidney injury (AKI) post heart surgery.