Study of Decrease in Plasma Antioxidants in Aged Osteoporotic Women in Vidharbha Region- Cross-Sectional Study

Abstract

INTRODUCTION: Vitamin C is an essential antioxidant that also functions as a cofactor in the production of healthy collagen in both increasing and mature tissues. Due to extreme vitamin C deficiency, scorbutic has an uneven and narrow growth layer, a thin trabecular network, poor collagen production, and a reduction in the differentiation of osteoblasts in mesenchymal cells. Insufficiency. pre-osteoblastic and osteoblastic cell lines, vitamin C increases collagen production, regenerated expression of vitamin D of alkaline phosphatase, and general mineral synthesis. When paired with vitamin C, TGF can stimulate osteoblast dissociation and, as a result, bone formation.

AIM: study of plasma antioxidants in aged osteoporotic women in vidharbha region.

MATERIAL AND METHOD: The articles were recruited consecutively between September and February 2020-21 among approximately 300 women who underwent orthopaedic tests in Geriatric patients focused on Observed Treatment Short-course at Dept. of OBGY

RESULT: The blood levels of vitamin C, vitamin E, vitamin A, and uric acid were always lower in osteoporotic patients than in controls (Table 2). Apart from that, none of the participants in the two groups had vitamin C or E levels that were significantly higher than the median. This supports the notion that, at least in terms of dietary antioxidants, all groups have sufficient nutritional status. Furthermore, antioxidant enzyme activities in plasma (SOD and GPx) and erythrocytes.

CONCLUSION: Osteoporotic women have weaker antioxidant defense than or mal age-matched control group. Further research into the pathways underlying antioxidant degradation and their relation to the pathogenesis of osteoporosis is required.