Effect of Acetylcystene on Endothelic Activity and Immuno-Inflammatory Processes in Acute Coronary Syndrome

Abstract

The study involved 100 hospitalized patients diagnosed with ACS in the form of ST segment elevation on an electrocardiogram at the age of 58.4 ± 10.5 years. In accordance with the tactics of treatment, they were divided into control (n = 50) and base (n = 50) groups. The control group was divided into two groups: patients receiving basal therapy (BT) in group I (n = 25) and coronary angioplasty (CA) in group II (n = 25).Therefore, the main group was assigned N-acetylcysteine (ACC) for 10 days. They were also divided into two groups and selected patients who received BT + ACC for group III (n = 25) and CA + ACC for group IV (n = 50). According to the results, the use of BT + ACC and CA + ACC from the first hours in patients after myocardial infarction has a positive effect on improving endothelial function by correcting the imbalance of the NO-system. At the same time, there is an improvement in the inflammatory process based on hypercytokinemia, that is, the cessation of IL-6 aggression. In addition, along with the improvement of hemodynamic parameters, it helps to restore the activity of the endothelium.