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The aim of this study is to assess the drug use pattern of antibiotics in post-operative patients using WHO prescribing indicators. It was a prospective and observational study was carried out in post-operative patients at Manipal Hospitals, Vijayawada. During the study period, we have collected a total number of 200 cases under surgical department. We found that most of the affected people were females with 56% (n= 112).Most of the people were under the age group of 40-60 years with 36% (n=72). The most common disease affected under the department is orthopaedics (29.5%). Drugs prescribed during post-operative stage were Antibiotics (100%), Analgesics (100%). Cephalosporin antibiotics were found to be the most frequently prescribed (89%). In analgesics NSAIDS and Non-Opioid analgesics were found to be the most frequently prescribed drugs with (72%) and (68.5%). In antiemetics Serotonin antagonists 48 (24%) was most frequently prescribed. Under the antiulcer drugs PPI’s (69%) followed by H2 blockers (17%), and Ulcer-protective agents (5%).No.of antibiotics per prescription were 3 antibiotics 77(38.5%). Total no of drugs per prescriptions were 4-6(8.5%), followed by 7-9 drugs (70%) etc. A total of 200 post-operative cases were collected. This report is intended to be a step in the broader evaluation safety and efficacy of drug prescription. This study shows the usage of prescription pattern of drugs in post-operative patients. This study shows that poly pharmacy was found to be very common which is mostly observed in case of antibiotics and lack of generic drug prescribing was observed. Drug prescribing from essential drug list (EDL) was low.